Epilepsy is a chronic neurological disorder characterized by abnormal neuronal
discharge, leading to recurrent and unpredictable disruptions in brain function. Despite
over 30 antiepileptic drugs (AEDs), 30% of patients develop drug-resistant epilepsy, requiring
combination therapy. This review explores epilepsy’s pathogenesis, including neuronal
hyperexcitability, neurotransmitter imbalances, and ion channel dysfunction, alongside
genetic, inflammatory, immune, and oxidative stress factors. AEDs are classified by mechanisms
like voltage-gated ion channel modulation and GABA/glutamate regulation, tracing
their evolution from traditional (e.g., phenobarbital) to modern therapies (e.g., lamotrigine).
Combination therapy, using complementary mechanisms (e.g., lacosamide with levetiracetam),
enhances efficacy but poses risks like drug interactions and cognitive impairment.
Integrating molecular biology and pharmacology advances, this review highlights the need
for rational drug selection and individualized strategies to improve epilepsy treatment
outcomes and patient quality of life. Future directions include personalized treatments,
optimized dosage forms, novel drug targets, and multi-target drugs(.Citation: Li, C.; Wang, X.; Deng, M.;
Luo, Q.; Yang, C.; Gu, Z.; Lin, S.; Luo,
Y.; Chen, L.; Li, Y.; et al. Antiepileptic
Drug Combinations for Epilepsy:
Mechanisms, Clinical Strategies, and
Future Prospects. Int. J. Mol. Sci. 2025,
26, 4035. https://doi.org/10.3390/
ijms26094035)
Looking forward to hearing from you all soon
Regards
Dr.Afshan .Hashmi

Meet and Greet with Dr. Afshan Hashmi is broadcast live Tuesdays at 3PM PT on K4HD Radio - Hollywood Talk Radio (www.k4hd.com) part of Talk 4 Radio (www.talk4radio.com) on the Talk 4 Media Network (www.talk4media.com) Meet and Greet with Dr. Afshan Hashmi TV Show is viewed on Talk 4 TV (www.talk4tv.com)

Meet and Greet with Dr. Afshan Hashmi Podcast is also available on Talk 4 Media (www.talk4media.com) Talk 4 Podcasting (www.talk4podcasting.com) iHeartRadio, Amazon Music, Pandora, Spotify, Audible, and over 100 other podcast outlets.