Research Paper: Mechanisms and Clinical Strategies, and Future Pros of Epilepsy- by Dr.Afshan Hashmi

0:01 This program is designed to provide general information with regards to the subject matters covered. This information is given with the understanding that neither the hosts, guests, sponsors or station are engaged in rendering any specific and personal medical, financial, legal, counseling, professional service, or any advice. You should seek the services of confident professionals before applying or trying any suggested ideas. Books, pdproducts, science, fashion and glam talk from Bollywood to Hollywood. It's meet and greet with doctor Ashan Hashmi right here on K FORHD radio and Talk for TV. And here's your host, international speaker, educator, award winning entrepreneur and best selling author, doctor Ashan Hashmi.

0:55 Hello everyone, this is your loving host and best selling author, doctor Rafshan Hajmi live from her studio in Rockville, Maryland. And today I will be talking in Meat and Get live on K four SHD Radio and Talk for TV. And today I will be talking about a research paper on epilepsy. But before I dive into that, and yes, I am PhD in biochemistry and also r A c RACK Regulatory Affairs satisfied and clinical Chemistry UH satisfied. You know from American Board of Clinical Chemistry American Board of Clinical Pathology, and here it is my qualifications are here.

1:39 And these are my two books. The first one is the Modern Mogle Mentality, New Strategies to Succeed in India and the global marketplace. And the second one is The Outbreak of a Monstrous Infection. When these two books came, you know, the first one a lot of research going on on jugar, which is which I have concepts as thinking outside the box and it is a common sense strategy. And from time to time I will give classes on this and if there are some exercises, if you do those exercises, you know, then you know I will recommend you for your coursework or anything. And the other one is The Outbreak of a Monstrous Infection. And both were Amazon best sellers. This one was Amazon bestseller in USA and India. And this was Amazon bestseller in USA. And this one was an hot number one new release on Amazon.

2:35 And I want a movie or a documentary to be made out of the first book and the second book. I want a a movie or a web series to be made or a TV serial. So all those Hollywood, Bollywood producers please contact me at Aughshan at Drrafshanhashbe dot com. And now let's you know, and this show will be syndicated worldwide to three hundred million listeners. So if you give me sponsorship, I will give you a very nice rate and you can contact me at Aughshan at Drfshanhashmi dot com. And now now, folks, you know, this is the paper anti Epileptic Drug Combinations for Epilepsy Mechanisms, Clinical Strategies and future prospects. So this is the one here and this is by Lee at All and it came in the journal International Journal of Molecular Sciences in twenty fifty twenty twenty five and volume six and paid four thousand and thirty five. So this is what it is, you know. And here is the paper and you can see the paper and let's do let me read you know, the abstract and I choose my own papers. So if you want, you know that you want your papers to be promoted, go to my website www dot Shanhashmi dot com and you will see the price on which and the papers which I choose. Of course, you know that that is free because I'm promoting the author because this

4:08 is a very good review paper and I went through the pub met of medline library, you know, and the Medical Library at NIH which caters to the whole world, you know, the online library. And I chose this paper on epileptic because you know, there is so many cases. Or I'm not a medical doctor, that is a disclaimer. I'm PhD and I have done a lot of clinical research as well as as well as you know I am. I know FDA law pertaining to FDA regulations and law, you know, so I know what FD law is. And I wanted to promote this epilepsy paper because every second person in United States I see here in Montgomery County have some kind of epileptic disorder. And my own husband, you know, I'm a widow now my own husband, you know, had had that cortico basal syndrome, which is an offshoot of epilepsy. I'm no medical doctor. I'm just a PhD person, but that's much I know. So having said that, you know, let's start this. Epilepsy is a chronic neurological disorder characterized by abnormal neuronal discharge leading to recurrent and unpredictable disruptions in brain function. Despite over thirty anti epileptic drugs. Thirty percent of patients developed resistant epilepsy, requiring combination therapy. This

5:40 review explodes epilepsies pathogenesis including neural hyper excitability, neurotransmitter imbalances, and iron change dysfunction, alongside genetic, inflammatory, immune, and oxidative stress factors. Oxidative is stress. My whole PhD was and my m film was on oxidative is stress related to unstable hemoglobins. And my m fill was and my PhD was on effects of finile hydrazine on red blood cell membranes, so it was oxidative stress related to red blood cell membranes. But here we are talking about the neurotransmitters and my research that Johns Hopkins was on neurotransmitters, So you know, I can understand that I worked on g proteins on Johns Hopkins University when I did my post doctor fellowship, so I can understand the oxidative stress very well. And now folks, I will go on a break and we'll be back soon.

6:38 Oh. Views around the group. This is doctor charm Hartman the Life for her. Radio show at Day Flour SHD and Top for TV show. And I just wanted to request you that w has given me a sponsorship. If you want to. Want this show to the having set adends, I will see you in another. Episode of K four ft Lately plus doc for TV show and if you give me a sponsorship, I will give you a very reasonable price and they'll also you will get a lot of promotion as this show is syndicated for right to more than four west years and bye bye.

7:27 Would you love exposure for your business, product or service to over three hundred million potential listeners? Send an email to in though at talkform media dot com and now let's hear from some of our sponsors. Chapter two, How Jugar leads to multi sector sex stories in India, including definitions of the Jugar management, principal business model of the book, the modern Mobal mentality, news strategies to succeed in India, and the global marketplace inspiration. True Jugar is an inspiration on how to create products using technology that meet the price value equation. According to a Harvard Business Review article featuring expert Prelard than marshalcre most innovation programs are built on the assumptions of affluence and abundance.

8:27 We see the rich and the young in both the developed and the developing countries demanding environmental friendly products and services. They also believe that affordability and sustainability are crucial to driving successful business Today, new technologies and radical business models are important not only to penetrate mass markets in India but in the entire world by reconfigure during all areas of the business structure. They will hold, Hey.

9:10 Monstrous infection is spreading worldwide. OMG. Is this a simple infection or a deliberate attempt to ruin the human population, or maybe it's bio terrorism. What is this global infection and who is spreading it? Help us find out. Go to Amazon and search for the outbreak of a monstrous infection. The human race nature helped to make this go viral. Go to Amazon dot com and read the outbreak of a Monstrous Infection to find out what happens next. Go now, the world is depending on you.

9:58 And now back to doctor oshon hash Mas radio shows. So now. It says that it ranks among the most common brain disorders globally, with an annual incidence rate ranging from fifty point four to eight point seven cases per one hundred thousand people. Approximately four point nine million new cases of epilepsy are diagnosed each year, contributing to a global burden of over seventy million people living with the condition. The disorder manifests through a variety of symptoms, including convulsions, loss of consciousness, muscle rigidity, muscle relaxation, and prolonged muscle contractions, which can significantly impact on individual's quality of life. The path of physology of epilepsy involves complex mechanisms such as abnormal neural finding, neurotransmitter imbalances and channel dysfunction, and genetic dispositions.

11:01 So what they are saying that it is also genetic and non genetic, so epileptic. And if there is a drug resistance to epilepsy, then you have to have a certain combinations of drugs. So it is a very very very thoughtful way. Now just think about this these days, you know, these illegal droning, illegal espinage is hitting people, you know, everywhere in Montgomery County. And when my husband was sick, the doctor, the doctor who was looking him before before the surgery, she was hit by an illegal drone, you know, and then she had to go. So just think if doctors are hit by illegal espinage and illegal droning while they are doing operations. You know how difficult their life is. My life has been so difficult for past more than twenty years, you know, And how I am surviving. I only you know, my parents, my younger brother, my and my husband were all taken away by illegal droning and illegal espionage. That how dangerous this technique is.

12:12 You know, you can kill anybody through these techniques by cyber threats, you know, and that is cyber terrorism. And I have written a book on bioterrorism to chemicals and these kind of things. If combined together, what a cocktail, detrimental cocktail will be made. And people who are killing for thrill, they have to understand that, you know, they cannot just go and spy on people's houses or anything without their permission. And this has happened to me. So I don't want anyone who's listening, you know, my three hundred million listeners that please please you know, if something is unusual, then please go and look about it. Having said that, you know, see they are saying that gaba urgic transmission enhancement and glutamate gluta mate receptive receptor inhibition, so there is you know, they say to manage epilepsy.

13:15 More than thirty anti epileptic drugs AEDs have been approof for clinical use, targeting diverse mechanisms including voltage gated iron channel and modulation, kaba urgic transmission enhancement, and glutamate receptor inhibition. In Figure one, some AEDs that have been a proof for the treatment of epilepsy are restrated despise these advancements. Approximately thirty percent of patients experience drug resistant epilepsy where monotherapy proves insufficient. So as I told you, there should have been a combination of things, and first generation at epileptic drugs are Klona. These are the molecular formulas and these are the drugs. Having said that, folks, you know now I and third see second generation because first stage, second stage, and third stage that's what they are saying.

14:11 And these are the drugs. So once an epileptic or any of those neurotransmitters have come, these are all terminal diseases. So people, please don't play with people's life by illegal droning and illegal espionage. I have lost my family you know because of that, So please, please please, I request you to be very careful and triber terrorism and cyber threats are very very eminent. Having said that, folks, now I will go on a break and will be backful. Around them. Which and top friends are life Mary in a country club.

14:59 And that's to see that. Ms Fields. To use the. Having said, please giving spons. And God, would you love exposure for your business, product or service to over three hundred million potential listeners. Send an email to info at talkformedia dot com And now let's hear from some of our sponsors.

15:47 A monstrous infection is spreading worldwide. Oh my god. Is this a simple infection or a deliberate attempt to ruin the human population, or maybe it's bio terrorism? What is this global infection and who is spreading it? Help us find out. Go to Amazon and search for the Outbreak of a Monstrous Infection. The human race needs your help to make this go viral. Go to Amazon dot com and read the Outbreak of a Monstrous Infection to find out what happens next. Go now, the world is depending on you.

16:34 The Outbreak of a Monstrous Infection Chapter one, nineteen sixty four to twenty eighteen. And this is the sample track and it is read by doctor Arafshan Nahid Hashmi in a sprawling banglaw in Potomac, Maryland, USA, live doctor Honey singh a both certified internal medicine and family practice physician, along with his beautiful wife be We Sing. Baby Sing was a fashionista and was funding women's causes through her Honey Bay Foundation. She had a lady's book club by the name of Baby's Glam and Glitzy Club, which had many glam and glitzy ladies who were professionals living in Washington, d C. Potomac, Maryland, Virginia, and even Beverly Hills, California, as well as a leach from all of America, meeting at her place on the last Wednesday of every month discussing various aspects of charities they wanted her and doctor Honey to fund. In this club, there was a wide spectrum of career women. There were doctors, lawyers, actresses, business owners, and models to name a few. In these book club meetings, members would come prepared after reading a book of a famous woman author, and that author was even invited from any part of the world to give her presentation, followed by a few and a in this prestigious and elite gathering.

18:05 And now thanks the doctor Oshon Hashme's radio. Shows Pathogens pathogenesis of epilepsy. So this is the diagram inflammation and impune response. It says the core pathology of epilepsy revolves around the synergy of abnormal neural discharges neurotransmitter imbalances, and I'm a channel dysfunction Figure two eight to twelve. So this is figure two from eight to twelve, and here it says that nerve imbalance damage oxidative stress causes nerved neurons to be in oxidative stress and then you know here the brain function and when they hit here at my hyperc alemus, you know, that's why I feel stress and I'm feeling so much of pain in my back.

19:01 Now this is inflammation. So these are some some neuron neurotransmitters TNF. These are also you know some cells called TNF neuro in in UH. These are the kind of responses that if TNF increases, you know, one beta and alpha tnf in there is an immune response and the neurons are excited. Neurons are brain cells, and inflammation and immune response, and then it goes to epilepsy and then Gatti Gaba Garber Garber neural inhibition. So these are some short forms and you can read the paper that for example that this regulation of glutamate and excitory neurotransmitter and are amino butteric acid GABA and inhibitorary neurotransmission is a hallmark of epilepsy. Gluta metrogenic hyperactivity induces calcium influx through N methyl d aspartate receptors, causing excitotoxicity, while GABA ergic intereuron loss or this function accelebates network hyper excitability. Molecular basis for channel pathis. So this is what it is.

20:22 And here see the mutation that if there is a mutation, like at the molecular level, you know there is a disk balance of the genetic code that is called mutation, and excited neurons are there and then so you know, if you are having illegal droning and people are getting hit by that, then your exxons are in excited state and stile polene receptors. See and mutation in sodium channel, potassium channel and calcium level. At the at the molecular level, the genetic factors, you know, suppose one chromosome is coming from the male and one coming from the female, and then they form an embryo, you know, and then the child is born after nine months, so that is what it is. Just see this normal neurons, excited neurons. So these are the normal neurons and these are the excited neurons.

21:23 See the shape difference. So if you see these kind of shapes, you know, if you can see you know, like by MicroB I know you cannot see the neurons, but you can feel it. If those drones you know, are put into you, you can see that these are excited neurons and normal neurons. I don't know what to say to this. And these are the short forms. It's a very good review paper, so please go and review that. And now I will go on a break and we'll be back through. Hello. Everyone, this is doctor Arashan Hashni live from a barn country club in Virginia, and I just wanted to say that my K four SHD radio and talk for TV show called Me Canry with Doctor Rashan Hashmi is syndicated worldwide and has more than three hundred million listeners. And if you want these shows to continue, please gave a sponsorship. And I request to please give a sponsorship because these shows require a lot of energy and money to produce. So I would request every one to give me sponsorship and your product quickly promoted in a very reasonable price. And you can contact me at Ufshan at Rrafshanhashmi dot com, pears and bye bye.

22:49 Would you love exposure for your business, product or service to over three hundred million potential listeners? Send an email to invo at talkformedia dot com and now let's hear from some of us. Chapter two, How Jugar leads to multi sector sex stories in India, including definitions of the Jugar management principal business model of the book, the modern moble mentality, news strategies to succeed in India and the global marketplace inspiration through Jugar is an inspiration on how to create products using technology that meet the price value equation. According to a Harvard Business Review article featuring expert prellad Than marshalcre most innovation programs are built on the assumptions of affluence and abundance.

23:50 We see the rich and the young in both the developed and the developing countries demanding environmental friendly products and services. They also believe that affordability and sustainability are crucial to driving successful business today. New technologies and radical business models are important not only to penetrate mass markets in India but in the entire world. By reconfigure during all areas of the business structure, they will polve.

24:32 Hey, monstrous infection is spreading worldwide. OMG. Is this a simple infection or a deliberate attempt to ruin the human population? Or maybe it's bioterrorism. What is this global infection and who is spreading it? Help us find out. Go to Amazon and search for the outbreak of a monstrous infection. The human race nature helped to make this go viral. Go to Amazon dot com and read the Outbreak of a monstrous infection to find out what happens next. Go now, the world is depending on you.

25:20 And now that's the doctor ash On Hashmi's radio show. So I was given induced drug via illegal espionage and illegal droning. And I am a very very clean person. And just see what benzodype benzodia zeppines do. And today my whole house was the smelling of carosine. So again gas was given. See this, see this. So this is the effects of various drugs on on on neurons. And you can go and read about it, and let me now talk about then there is combination therapy is clinical evidence.

26:04 Pharmaco therapy remains the primary approach for epilepsy and rational combination therapy has emerged as a critical strategy. And the other thing is okay, So now, yes, I wanted to show the adverse reaction. Yes, see it says monitoring adverse reactions, you have to report the drug interactions. You know, you just can't mix things. You know, if benzo dipi diopisines the drug, you know that at carc drugs you know, and m fetemines are mixed with people who are taking drugs for relaxation and sleeping, you know, it can cause a very very detrimental effect. And then you have to report it to the FDA. But that and you have to report it to FDA or you can report it to your physician. And see, that is what adverse reaction monitoring is and being an FD regulatory affairs respectuless, I know how to report adverse reactions to FDA. And see this, So now folks, I will go on a break and we'll be back soon.

27:11 Viewers around the group, This is doctor of Charm Hatchman the Live for. Her radio show at K four SHB and Talk for TV Show, And I just wanted to request you that please give me a sponsorship if you want to want this show to continue. Having set that, friends, I will see you in another episode of K four st Radio plus Talk for TV Show. And if you give me sponsorship, I will give you a very reasonable price and we'll also you will get a lot of promotion as this show is syndicated worldwide.

27:52 To move them through. Cheers and bye bye. Would you love exposure for your business, product or service to over three hundred million potential listeners? Send an email to info AT's talkform media dot com and now let's hear from some of our sponsors. Chapter two, How Jugar leads to multi sector sex stories in India, including definitions of the Jugar management principal business model of the book, the modern Mobile mentality, news strategies to succeed in India and the global marketplace. Inspiration through Jugar is an inspiration on how to create products using technology that meet the price value equation. According to a Harvard Business Review article featuring expert prellad Than Marshalker, most innovation programs are built on the assumptions of affluence and abundance.

29:00 We see the rich and the young in both the developed and the developing countries demanding environmental friendly products and services. They also believe that affordability and sustainability are crucial to driving successful business Today. New technologies and radical business models are important not only to penetrate mass markets in India but in the entire world. By reconfigure during all areas of the business structure, they will pold.

29:43 Hey, monster's infection is spreading worldwide. OMG. Is this a simple infection or deliberate chempt to ruin the human population? Or maybe it's by terrorism. What is this global infection and who is spreading it? Help us find out. Go to Amazon and search for the outbreak of a monstrous infection. The human race needs your help to make this go viral. Go to amazon dot com and read the Outbreak of a Monstrous Infection to find out what happens next. Go now, the world is depending on you.

30:31 And now back to doctor oshon Hashmes radio show. Molecular toxicity mechanisms nano drug and PROCEPTREGA, bilin and syringe. So these are some personalized treatment based on molecular mechanisms. So this is a diagram here, and folks, so let me talk little little bit. When you have any pain here in your brain or anything, and someone is pressing and you can't see the person, that is what is illegal droning and illegal espinage if somebody is putting pressure on your thing because and whatever was done to me was done without informed consent and without my knowledge, without my husband's knowledge. So this is what illegal espinage and illegal droning is that you get into somebody's house without their permission and start droning and start doing clinical trials.

31:32 And these are all illegal clinical trials. And if a pharmaceutical company CEO is punished for illegal trials, then whoever is whoever does that on American soil and kills people, is equally responsible. And go and read twenty one CFAR three hundred and twelve and twenty one CFAR six hundreds and you will know that what actually that is. Having said that, folks, you know and no informed consent was taken, and nobody can pressure anybody after the clinical trials are done to sign the informed content because the damage is already done to the body. See my life, my parents, my younger autistic brother, and me and my husband. They've all dead and now they are doing again illegal clinical trials and they give those roans to small children and people to play with it with human body. Is it very fair? Folks? You know you have for killing people for thrill? What is all this nonsense? I just cannot understand that. And because everyone, you know, I see so much of disease of epilepsy. You know, people can't walk, which is in the terminal stage, you know. And no treatment was given to my husband, so it was induced death of my husband. That means it was induced killing.

32:59 And how my life is disturbed And how I have been approoted because of illegal clinical trials and illegal you know, I only know how I how how I'm with the day to day problem. I was not actually prepared for it. So you should have a life insurance and everything and your will and everything prepared, you know, and be independent, you know, so that is this calamity falls on you, you are prepared. Of course, rich billionaires you know, Uh, it's there, it's their idea you know, to do go into take expeditions, to move, take expeditions here and there and do and see the effects of illegal clinical trials.

33:48 You know, but those billionnaires have to understand that we are American people and we will not we will not, you know, be subjected to this kind of thing, you know, and political game. You know that how much money you will give to this party according to that you buy the post. You know, like if you give six hundred million dollars, you will get this if you cannot afford, if you afford ten dollars, you know, you are giving your food. You know, in ten dollars, somebody can have meal. So this is all what the problem is that politics has become so so cheap and it looks like pankataila, which means you know that it's a punchiety election of India and you can think of a third world country.

34:39 That is what the American politics has begun, has become. And just see this. I love Israel, but please pre Palestine and no bombing. You know, people who are bombed every day, that how they feel. And if it is illegal droning and illegal espionage, that is also illegal bombing. You know, you are bombing Americans citizens with this and you are putting them in that stress. Why this kind of strategy is there? People should heal. You know why my husband was not given given the right treatment. Why you know, I had a fall and that was an induced fall. That's how it all started in my life.

35:19 You know, after that fall, I cannot stand for extended periods of time. So how my life is this theb to these billionaires? And do these politicians understand that? Having said, and they just come on TV and they are just fighting Democrats fighting with Republicans and Republicans fighting with Democrats. Whereas United States of America, I am suggesting, I want to be a I want to be a peace maker. And I have taught Islam to President Biden and President Prompt, so I know both of them personally, and I want, you know, to actually bring peace together. What happened that day in correspondent dinner. Whenever President Trump goes out he gets an assassination attack, is it very fair to him?

36:11 Who will take be president? You know? Do you want cartels to you know, be president and ruin America? And the same thing happened with President Biden. You know, so I know the inside the story. So please please, you know, please please think before voting, and all cartils and all terrorists should be removed. You know how much law enforcement could do. Even American citizens are responsible for peacemaking, you know. Having said that, folks, now I will see you in next episode of Beat and Breet and my docor series. And after this, I am going to give life promoting the King Charles Dinner, So please come and join me from seven as far it is, and I will be going to undisclosed destination, so I will not be here.

37:03 I will be going to our undisclosed destination to give that. Having said that, folks, deals and bye bye and see you next Tuesday at six pm US Eastern time. You've been listening to Meet and Greet with Doctor Afshan Hashmi on k for HD radio and Talk for TV. Tune in live right here every Thursday at six pm Eastern time. Would you love exposure to your business, product or service to over three hundred million potential listeners. Send an email to info at talkfourmedia dot com, and remember, if you miss any part of the show or want to hear it again, find our featured show on iHeartRadio or YouTube, where all past episodes are available on demand.

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